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产品信息
ABS 022-03-02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
3
抗原
Purified, recombinant Leptin.
偶联物
形式
Liquid
浓度
1.09 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_667480
产品详细信息
ABS 022-03-02 detects Leptin in human samples.
ABS 022-03-02 has been successfully used in ELISA and immunohistochemistry procedures. ABS 022-03-02 binds free Leptin in solution. In sandwich ELISA, ABS 022-03-02 works as a capture antibody with ABS 022-11-02 as a detection antibody.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
靶标信息
Leptin is a 167 amino acid long protein hormone with important effects in regulating body weight, metabolism and reproductive function. Leptin is approximately 16 kDa in mass and encoded by the obese (ob) gene. Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body. Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta. Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells. Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure. Leptin is involved in regulating food intake, energy expenditure, and adiposity through hypothalamic leptin receptors. Leptin promotes hematopoiesis, angiogenesis, wound healing, inflammation, immune responses, influences pubertal development and fetal growth. Studies have investigated the role of leptin in obesity, anorexia nervosa, insulin resistance, and hypertension. Leptin also has thermogenic actions and regulates enzymes of fatty acid oxidation. Severe hereditary obesity in rodents and humans can be caused by defects in leptin production.
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生物信息学
蛋白别名: CD295 antigen; H-Leptin; HuB219; LEP-R; Leptin; leptin (murine obesity homolog); leptin (obesity homolog, mouse); OB-R; Obese protein; obese, mouse, homolog of; obesity; Obesity factor; obesity protein
基因别名: LEP; LEPD; OB; OBS
UniProt ID: (Human) P41159
Entrez Gene ID: (Human) 3952
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
ovulation from ovarian follicle
response to hypoxia
positive regulation of cytokine production
placenta development
regulation of endothelial cell proliferation
response to dietary excess
cardiac muscle hypertrophy
glucose metabolic process
regulation of gluconeogenesis
energy reserve metabolic process
glycerol biosynthetic process
lipid metabolic process
fatty acid beta-oxidation
tyrosine phosphorylation of STAT protein
female pregnancy
circadian rhythm
cholesterol metabolic process
bile acid metabolic process
regulation of blood pressure
adult feeding behavior
negative regulation of autophagy
negative regulation of lipid storage
positive regulation of phosphatidylinositol 3-kinase signaling
response to activity
sexual reproduction
central nervous system neuron development
insulin secretion
T cell differentiation
regulation of intestinal cholesterol absorption
positive regulation of TOR signaling
negative regulation of appetite
prostaglandin secretion
response to estradiol
regulation of natural killer cell activation
regulation of natural killer cell proliferation
response to insulin
response to vitamin E
leptin-mediated signaling pathway
positive regulation of luteinizing hormone secretion
positive regulation of peroxisome proliferator activated receptor signaling pathway
bone mineralization involved in bone maturation
negative regulation of appetite by leptin-mediated signaling pathway
positive regulation of T cell proliferation
regulation of natural killer cell mediated cytotoxicity
hormone metabolic process
positive regulation of tyrosine phosphorylation of Stat3 protein
glucose homeostasis
eating behavior
negative regulation of apoptotic process
positive regulation of ion transport
positive regulation of MAPK cascade
cellular response to leptin stimulus
response to ethanol
positive regulation of myeloid cell differentiation
regulation of angiogenesis
negative regulation of vasoconstriction
negative regulation of glucose import
positive regulation of JAK-STAT cascade
positive regulation of insulin receptor signaling pathway
regulation of bone remodeling
positive regulation of follicle-stimulating hormone secretion
positive regulation of developmental growth
regulation of insulin secretion
regulation of steroid biosynthetic process
intestinal absorption
leukocyte tethering or rolling
regulation of nitric-oxide synthase activity
regulation of cell cycle
positive regulation of protein kinase B signaling
regulation of lipoprotein lipid oxidation
adipose tissue development
negative regulation of cartilage development
negative regulation of glucagon secretion
cellular response to L-ascorbic acid
cellular response to retinoic acid
interleukin-6 secretion
interleukin-8 secretion
regulation of brown fat cell differentiation
bone growth
regulation of cytokine production involved in inflammatory response
positive regulation of p38MAPK cascade
positive regulation of fat cell apoptotic process
activation of protein kinase C activity
positive regulation of STAT protein import into nucleus
positive regulation of reactive oxygen species metabolic process
negative regulation of glutamine transport
positive regulation of hepatic stellate cell activation
